Table 1.

Effects of ghrelin administered intraperitoneally (3 nmol/mouse every 12 hours for five days) on calorie intake, epididymal fat mass, gastrocnemius muscle, and blood glucose, insulin, cholesterol, triglycerides, and free fatty acid concentrations in lean mice under a high fat diet

	LF, saline	HF, saline	HF, ghrelin
Calorie intake (kcal/day)	18.83 (1.055)	23.22 (1.329)	25.94 (2.562)*
Fat pad mass(g)	0.533 (0.049)	0.797 (0.095)	1.202 (0.175)**†
Skeletal musde (g)	0.337 (0.016)	0.353 (0.010)	0.340 (0.005)
Glucose (mmol/l)	7.899 (0.476)	8.393 (0.825)	8.909 (0.498)
Insulin (pmol/l)	135.0 (20.10)	177.5 (13.05)	378.0 (141.8)*
Cholesterol (mmol/l)	3.742 (0.337)	5.568 (0.497)	5.813 (0.509)**
Triglycerides (mmol/l)	0.347 (0.032)	0.305 (0.039)	0.371 (0.090)
Free fatty acids (meq/l)	1.467 (0.050)	1.623 (0.100)	1.636 (0.047)

Results are expressed as mean (SEM).

LF and HF indicate a standard diet and a high fat diet, respectively.

*p<0.05, **p<0.01 between saline treated mice fed a standard diet and ghrelin treated mice fed a high fat diet.

†p<0.05 between saline treated mice fed a high fat diet and ghrelin treated mice fed a high fat diet.