Table 2.
Twenty four hour urine excretion of aquaporin 2 (AQP2), free water clearance (ClH20), osmolar clearance, urine volume, 24 hour osmolality, urine and serum osmolality, and plasma vasopressin in control subjects and patients with cirrhosis stratified according to their Child-Pugh score
| Controls | Child A | Child B | Child C | |
| AQP2 (U/24 h) | 0.021 (0.017) | 0.040 (0.039) | 0.092 (0.160) | 0.315 (0.348)† |
| ClH20 (ml/min) | −1.3 (0.56) | 0.19 (0.24)††† | −0.17 (0.37)*††† | −0.38 (0.39)*††† |
| U-volume (l/24 h) | 1.8 (0.7) | 2.0 (0.6) | 1.8 (1.2) | 1.6 (0.8) |
| Closm (mmol/min) | 3.8 (0.7) | 1.7 (0.8)††† | 2.0 (1.3)†† | 2.2 (1.0)†† |
| 24 h osmol (mosmol/24 h) | 1046 (190) | 478 (244)††† | 559 (369)††† | 572 (264)††† |
| U-osmolality (mosmol/l) | 643 (220) | 239 (50)††† | 335 (86)*† | 395 (154)*†† |
| S-osmolality (mosmol/l) | 282 (11) | 281 (7) | 280 (10) | 266 (20) |
| P-vasopressin (pg/ml)§ | — | 0.52 (0.80) | 0.71 (0.51) | 0.64 (0.48) |
Data are mean (SD).
*p<0.05 Child Pugh class C or B versus A.
†p<0.05, ††p<0.01, †††p<0.005 versus controls.
§Child Pugh class A, n=1; class B, n=10; class C, n=9.