Table 2.

Changes in liver function and SIRS components prior to and after treatment with Infliximab

	Baseline (day –2)	Day 1	Day 7	Day 14	Day 28
Prothrombin time [10–13] (s)	20.7 (1.7)	20.1 (1.8)	18.8 (1.6)*	18.3 (1.2)*	17.8 (0.9)**
Bilirubin [3–17] (μmol/l)	335.9 (41.6)	285.5 (48.2)	267.6 (43.4)	219.2 (40.4)*	141.1 (17.7)*
C reactive protein [0–5] (mg/l)	86.8 (13.7)	53.1 (9.2)**	48.7 (10.3)**	39.2 (5.6)***	32.7 (4.6)***
White blood cell count [3–10] (×109/l)	17.5 (2.7)	13.5 (1.6)**	13.8 (1.6)**	13.5 (1.2)**	12.3 (1.8)***
Temperature (°C)	37.7 (0.3)	37 (0.2)*	37 (0.3)*	36.8 (0.2)*	36.8 (0.2)*
Heart rate (beats/min)	93.8 (3.7)	85.3 (3.1)*	85.7 (2.9)*	79 (3.2)**	73.5 (1.6)***
Respiratory rate (/min)	22.3 (1.5)	18.7 (1.1)*	18.5 (2.1)*	17.1 (0.8)*	17.7 (1.1)*

*p<0.05, **p<0.01, ***p<0.001 compared with baseline values.

Values are mean (SEM) [normal range].

SIRS, systemic inflammatory response syndrome.