Figure 4.

Effect of intravenous injection of indomethacin (IDM) on the area of ethanol (EtOH) induced gastric lesions reduced by capsaicin (Cap), and changes in calcitonin gene related peptide (CGRP) levels released during perfusion. Perfusion was performed in wild-type mice (C57BL/6) according to the protocol described in materials and methods. The reddened area reduced by simultaneous perfusion of capsaicin was restored by intravenous injection of indomethacin. Indomethacin reduced levels of CGRP released by ethanol+capsaicin to basal control values. Values are expressed as means (SEM) from five to six mice. ANOVA was used for statistical analysis: *p<0.05; **p<0.01; ***p<0.001.