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. 2003 Sep;52(9):1304–1307. doi: 10.1136/gut.52.9.1304

Figure 1.

Figure 1

Morphological characteristics of the adenoma-carcinoma transition. Representative photographs of haematoxylin-eosin stained sections of adenoma (A) with high grade dysplasia (HGD) showing increased mitotic figures and a cribriform architecture. Epithelial cells in HGD are characterised by loss of polarity of the cells, and enlarged and pleomorphic nuclei. (A) Adenoma-carcinoma transition: the adenoma (A) on the right shows typical epithelial cells in a single cell layer whereas HGD on the left shows multiple layers of dysplastic epithelial cells (magnification bar 200 μm). (B) Adenoma-carcinoma transition: HGD at the top of the image includes epithelial cells with pleomorphic nuclei and mitotic figures, whereas the adenoma (A) at the bottom shows polarised epithelial cells and goblet cells. CT, connective tissue (magnification bar 50 μm). (C, D) Representative photographs of haematoxylin-eosin stained sections showing connective tissue cells (C) in the adenoma (A) and (D) in HGD (magnification bars 50 μm).