Table 2.

Role of cyclooxygenase 2 in elevated colonic bacterial colonisation and translocation following resolution of colitis

Group	Total aerobes (log10 CFU/g)	Incidence of translocation (%)
Control+vehicle	5.40 (0.34)	2/10 (20)
Post-colitis+vehicle	6.47 (0.31)*	8/11 (73)*
Post-colitis+rofecoxib	6.05 (0.29)	2/11 (18)†

Colonic bacterial colonisation and translocation to the spleen were measured six weeks after trinitrobenzene sulphonic acid administration (controls were age matched). Treatment with rofecoxib (3 mg/kg) or vehicle was performed twice daily for the week prior to the rats being killed.

*p<0.05 versus the control group; †p<0.05 versus the post-colitis+vehicle group.