Table 2.

Severity of side effects†

Side effect	Baseline		Month 1		Months 2–3		Months 4–6
	Placebo	Amantadine	Placebo	Amantadine	Placebo	Amantadine	Placebo	Amantadine
Fatigue	1.52 (1.48)	1.21 (1.41)	1.99 (1.42)	2.09 (1.35)***	2.09 (1.47)*	2.14 (1.24)***	1.97 (1.59)	1.94 (1.28)**
Anorexia	0.06 (0.4)	0.13 (0.53)	0.46 (0.93)**	0.67 (1.02)***	0.53 (1.06)***	0.5 (0.79)**	0.41 (0.88)**	0.29 (0.7)
Lack of exercise tolerance	0.76 (1.38)	0.81 (1.34)	0.97 (1.38)	1.37 (1.55)*	1.30 (1.61)*	1.47 (1.48)*	1.4 (1.67)*	1.52 (1.53)**
Nausea	0.29 (0.85)	0.23 (0.69)	0.82 (1.08)**	0.81 (1.08)***	0.64 (0.98)*	0.71 (0.94)**	0.46 (0.96)	0.57 (0.93)*
Malaise	0.75 (1.46)	0.44 (1)	1.02 (1.25)	1.16 (1.37)***	1.05 (1.41)	1.15 (1.37)**	1.05 (1.56)	1.01 (1.50)*
Itching	0.63 (1.25)	0.53 (0.97)	0.69 (1.09)	0.92 (1.14)*	0.95 (1.24)	1.12 (1.19)**	1.11 (1.46)	1.44 (1.46)***
Weight loss	0.11 (0.49)	0.08 (0.34)	0.27 (0.51)*	0.39 (0.58)***	0.39 (0.71)**	0.36 (0.53)***	0.36 (0.61)*	0.36 (0.61)**
Depression	0.33 (0.77)	0.31 (0.71)	0.71 (1.1)*	0.84 (1.17)**	0.8 (1.18)**	0.91 (1.14)***	0.95 (1.26)**	0.68 (1.05)*
Insomnia	0.96 (1.47)	0.54 (1.14)	1.05 (1.41)	1.42 (1.4)***	1.18 (1.27)	1.32 (1.31)***	1.41 (1.58)	1.47 (1.33)***
Dizziness	0.09 (0.29)	0.21 (0.69)	0.58 (0.92)***	0.68 (1.05)**	0.63 (1.08)***	0.78 (1.02)***	0.38 (0.79)**	0.61 (0.94)*
Blurred vision	0.48 (0.99)	0.36 (0.89)	0.47 (0.94)	0.6 (1.02)	0.63 (1.2)	0.61 (0.96)	0.55 (1.12)	0.49 (1.03)
Nervousness	0.54 (1.02)	0.51 (1.06)	0.51 (0.89)	0.8 (1.15)	0.66 (0.95)	0.82 (1.23)	0.78 (1.21)	0.66 (1.23)
Dry mouth	0.86 (1.48)	0.57 (1.26)	1.29 (1.52)	1.45 (1.45)***	1.5 (1.65)*	1.58 (1.63)***	1.47 (1.62)*	1.63 (1.51)***

†Severity scored on a scale from 0 (none) to 5 (severe), and results are expressed as mean (SD).

*p<0.05, **p<0.01, ***p<0.001 compared with baseline. There were no significant differences between amantadine and placebo at different time intervals. There were no significant changes in side effects after month 1 in both groups.