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. 2004 Jan;53(1):27–33. doi: 10.1136/gut.53.1.27

Figure 2.

Figure 2

Histology (A–D) and immunohistochemical staining (E–P) of the oesophagogastric junction and Barrett’s oesophagus. (A, E, I, M) normal oesophagogastric junction; (B, F, J, N) short Barrett’s oesophagus; (C, G, K, O) long Barrett’s oesophagus; (D, H, L, P) atypical Barrett’s oesophagus; (E-H) cyclooxygenase 2 (COX-2); (I–L) COX-1; (M–P) microsomal prostaglandin E synthase 1 (mPGES-1). The normal oesophagogastric junction showed COX-1 in subepithelial stromal cells and did not express COX-2 or mPGES-1. All types of Barrett’s oesophagus showed expression of COX-1, COX-2, and mPGES-1 in subepithelial stromal cells. In atypical Barrett’s oesophagus, COX-2 immunoreactivity was observed not only in stromal cells but also in metaplastic columnar cells. Magnification: (C) ×100; (B, D) ×200; (A, E–P) ×400.