Figure 6.

Norepinephrine (NE) activates adrenoceptor G protein coupled mechanisms that induce mitogenic and survival pathways in hepatic stellate cells (HSC). HSC pooled from six normal mice were cultured with NE (10 μM) or NE with pertussis toxin (NE+PT), wortmannin (NE+WT), PD98059 (NE+PD), SB202190 (NE+SB), or Ro-32-0432 (NE+RO). After two days, HSC numbers were evaluated in triplicate wells. Mean (SEM) results of duplicate experiments are shown. *p<0.05 for inhibitor treated versus NE alone.