Figure 6.

Increased susceptibility of Id2 deficient mice after 5-fluorouracil (5-FU) treatment. (A) Survival rate of mice after 5-FU treatment. Id2^+/+ and Id2^−/− mice were treated intraperitoneally with 800 mg/kg 5-FU. Eight mice were used in each group. (B) Translocation of endogenous bacteria from the intestine to the liver and spleen in mice treated with 5-FU. Numbers of bacteria in the liver and spleen of Id2^+/+ and Id2^−/− mice were determined on the indicated days after intraperitoneally injection of 800 mg/kg 5-FU. Values represent mean (SEM) of three animals. *p<0.05, as determined by the Student’s two tailed t test.