Figure 4.

Effect of subcutaneous inoculation of L salivarius 118 and phosphate buffered saline (PBS) on paw thickness (A), total inflammation in all limbs (B), inflammation in the fore limbs (C), and inflammation in the hind limbs (D), in collagen induced arthritis. The thickness of each paw was measured with spring loaded callipers. Total paw swelling for each mouse was calculated by adding the thickness of the individual paws. Paw thickness of the unaffected/negative control group was taken as 0. Results (A–D) are expressed as mean (SEM). The L salivarius 118 group showed a significant reduction in paw thickness compared with controls (n = 10 per group).