Figure 5.
Effect of BN52021 on femoral arterial and portal venous pressure of cirrhotic rats. After eight weeks of vehicle or carbon tetrachloride (CCl4) treatment, rats were anaesthetised and their femoral arterial and portal venous pressures determined. Following stabilisation (five minutes), BN52021 (5 mg/kg) was infused via the portal vein for one minute using a 23 gauge needle with the aid of a 975 Harvard compact infusion pump. Values shown are from six rats (mean (SD)) 5–6 minutes after introduction of BN52021 when the pressure stabilised to a constant value. *p<0.05 versus basal value.