Figure 2.

Schematic diagram of the structure of a first generation bioreactor (extracorporeal liver assist device (ELAD), with plasma passing through the intracapillary space, and hepatocytes derived from human hepatoblastoma based cell lines in the extracapillary space), a newer generation bioreactor (AMC-BAL, incorporating a spirally wound polyester matrix sheet that includes an integral hollow fibre compartment for oxygenation), and an artificial device dialyser (molecular adsorbents recirculating system (MARS), with blood passing through the intracapillary space, and separated from the extracapillary 20% albumin dialysate by an albumin impregnated membrane).