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. 2004 Jun;53(6):829–837. doi: 10.1136/gut.2003.030882

Figure 1.

Figure 1

Candidate polymorphic or mutated genes involved in altered adrenergic and serotonergic functions. Top: α2A and α2C adrenoreceptor polymorphisms. α2A −1291 (C→G), cytosine to guanine transversion in promoter of α2A receptor protein; α2ALys251, a cytosine to guanine transversion at position 753 that changes amino acid 251 of the third intracellular loop of the α2A adrenoceptor from asparagine to lysine; α2C Del 322–325, deletion in third intracellular loop of α2C adrenoceptor protein. Middle: norepinephrine transporter (NET). Bottom: solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 (SLC6A4) (serotonin transporter promoter (SERT-P)).