Figure 3.
Electrical stimulation (ES) induced increase in motility indices of the mid sigmoid colon in irritable bowel syndrome (IBS) patients was blocked by administration of α-helical corticotropin releasing hormone (CRH)9–41 (10 μg/kg). Intravenous administration of α-helical CRH9–41 is indicated by the hatched bar. Data are expressed as mean (SEM). B1: baseline, ES1: electrical stimulation of the rectum, and R1: recovery, in the first stage of the experiment. B2: baseline, ES2: electrical stimulation of the rectum, and R2: recovery in the second stage (hatched bar). *p<0.05 compared with controls by the Mann-Whitney U test; †p<0.05 compared with ES1 or R1 by the paired t test; ‡p<0.05 compared with B2 by the paired t test.