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Effect of substance P (SP) on the number of days with rotavirus diarrhoea (NDD). SP receptor antagonism was studied using neurokinin 1 receptor knockout mice (NK-1 R−/−), the SP receptor antagonist (D-Pro2, D-Trp7, 9)-SP (SP-ant), and NK-1 receptor antagonists (Sendide and CP-96,345). Values above the columns indicate the number of mice. Values are means (SEM). **p<0.01 compared with controls (Student’s t test).
