Table 3.
Toll-like receptor 4 (TLR4) genotypes in the study populations
CD cohort 1 (n = 334)* | CD cohort 2 (n = 113)** | UC (n = 163)*** | Controls (n = 139) | |
Genotype | ||||
Wild-type | 265 (79.3%) | 88 (77.9%) | 133 (81.6%) | 126 (90.6%) |
Heterozygous | 65 (19.5%) | 24 (21.2%) | 28 (17.2%) | 12 (8.6%) |
Homozygous mutant | 4 (1.2%) | 1 (0.9%) | 2 (1.2%) | 1 (0.8%) |
Allele frequencies | ||||
Minor allele | 10.9% | 11.5% | 9.8% | 5.0% |
CD, Crohn’s disease; UC, ulcerative colitis.
All p values are compared with controls: *p = 0.012, **p = 0.017, ***p = 0.08.