Figure 1.

 A diagrammatic representation of the complex interrelationship between peripheral and central (hypothalamic) neuropeptides for regulation of feeding. Stimulation by orexigenic pathways results in food intake; stimulation of anorexigenic pathways leads to satiety. Continuous lines represent stimulating pathways, broken lines indicate suppressive actions. NPY, neuropeptide Y; AgRP, argouti related peptide; POMC, pro-opiomelanocortin; PYY, peptide YY; Y21, Y2R, postsynaptic NPY receptors; Cart, cocaine amphetamine regulated transcript; MC3R, MC4R, melanocortin receptor 3 and 4; MCH, melanin concentrating hormone; GLP-1, glucagon-like peptide.