Table 1.
Percentage of mice with the appearance of bloody faeces, rectal prolapse, or cachexia (evidenced by progressive weight loss (>30% loss compared with initial body weight) and signs of muscle wasting). Colonic neoplasms were induced by 1,2-dimethylhydrazine and mice then underwent a treatment free period before daily treatment with native glucagon-like peptide 2 (GLP-2), Gly2-GLP-2, or phosphate buffered saline (controls)
| Controls | GLP-2 | Gly2-GLP-2 | |
| 2 month treatment free interval (2MO) | |||
| 10 days of treatment | |||
| Bloody faeces | 10 | 11 | 11 |
| Rectal prolapse | 40 | 39 | 37 |
| Cachexia | 0 | 6 | 0 |
| 1 month of treatment | |||
| Bloody faeces | 0 | 0 | 0 |
| Rectal prolapse | 21 | 15 | 26 |
| Cachexia | 0 | 0 | 4 |
| 3 month treatment free interval (3MO) | |||
| 1 month of treatment | |||
| Bloody faeces | 16 | 0 | 11 |
| Rectal prolapse | 40 | 19 | 28 |
| Cachexia | 7 | 7 | 33 |