Table 2.
Body weight and proportion of tumour bearing animals. Colonic neoplasms were induced by 1,2-dimethylhydrazine and mice then underwent a treatment free period before daily treatment with native glucagon-like peptide 2 (GLP-2), Gly2-GLP-2, or phosphate buffered saline (controls)
| Controls | GLP-2 | Gly2-GLP-2 | |
| 2 month treatment free interval (2MO) | |||
| 10 days of treatment | |||
| Survival (%) | 100 | 95 | 100 |
| Initial body weight (mg) | 23.6 (0.2) | 23.1 (0.2) | 23.3 (0.3) |
| Final body weight (mg) | 23.2 (0.2) | 23.3 (0.3) | 23.5 (0.2) |
| Tumour bearing animals (%) | 100 | 100 | 100 |
| Animals with small tumours (%) | 100 | 100 | 100 |
| Animals with medium sized tumours (%) | 95 | 77 | 95 |
| Animals with large tumours (%) | 90 | 72 | 84 |
| 1 month of treatment | |||
| Survival (%) | 96 | 100 | 96 |
| Initial body weight (mg) | 23.9 (0.2) | 23.4 (0.2) | 23.6 (0.2) |
| Final body weight (mg) | 22.9 (0.2)† | 23.2 (0.2) | 23.8 (0.2)** |
| Tumour bearing animals (%) | 100 | 100 | 100 |
| Animals with small tumours (%) | 100 | 100 | 100 |
| Animals with medium sized tumours (%) | 70 | 65 | 78 |
| Animals with large tumours (%) | 83 | 55 | 83 |
| 3 month treatment free interval (3MO) | |||
| 1 month of treatment | |||
| Survival (%) | 94 | 93 | 75 |
| Initial body weight (mg) | 23.6 (0.2) | 23.4 (0.2) | 24.0 (0.3)* |
| Final body weight (mg) | 23.5 (0.2) | 23.6 (0.2) | 24.7 (0.4)** |
| Tumour bearing animals (%) | 100 | 100 | 100 |
| Animals with small tumours (%) | 100 | 100 | ‡ |
| Animals with medium sized tumours (%) | 96 | 96 | 100 |
| Animals with large tumours (%) | 76 | 63 | 100 |
Results are mean values and SEM.
‡Numerous small sized tumours formed larger conglomerates which made it impossible to count the exact number.
*p<0.05, **p<0.01 versus control and GLP-2. †p<0.05 versus initial body weight.