Table 4.
Helicobacter pylori eradication with triple therapy (proton pump inhibitor-amoxicillin-clarithromycin) according to clarithromycin susceptibility or resistance
| Reference | Type of study | Treatment | Eradication rate | ||
| Overall | Clarithromycin susceptible | Clarithromycin resistant | |||
| Bago10 | Randomised | OAC 1 week | 84% (37/44) | 89.7% (35/39) | 40% (2/5) |
| Bochenek94 | Randomised | PAC 1 week | 66.5% (137/206) | 77.3% (130/182 | 29.1% (7/24) |
| Ducons95 | Successive | LAC 1 week | 79% (79/100) | 85.5% (77/90) | 20% (2/10) |
| Hoshiya96 | Not randomised | OAC, LAC 1 week | 77.5% (83/107) | 83.1% (79/95) | 33.3% (4/12) |
| Kalach97† | Successive | OAC, LAC 1 week | 81.9% (50/61) | 100% (50/50) | 0% (0/11) |
| Katelaris98 | Randomised | PAC 1 week | 80.4% (37/46) | 86% (36/42) | 25% (1/4) |
| Kawabata99 | Randomised | LAC, RAC 1 week | 78% (135/173) | 85.5% (130/152) | 23.8% (5/21) |
| Kihira100 | Randomised | RAC | 92.6% (79/85) | 96.3% (79/82) | 0% (0/3) |
| Laine25 | Randomised | OAC | 85.8% (91/106) | 94.6% (88/93) | 23% (3/13) |
| Lamouliatte101 | Randomised | PAC 1 week | 81.1% (82/101) | 86% (82/95) | 0% (0/6) |
| Lamouliatte102* | Randomised | OAC 1 or 2 weeks | 48.3% (57/118) | 80% (48/60) | 15.5% (9/58) |
| Lehman103 | Randomised | LAC 2 weeks | 72% (23/32) | 87% (23/29) | 0% (0/3) |
| Lind104 | Randomised | OAC 1 week | 95.7% (113/118) | 97% (111/116) | 100% (2/2) |
| McMahon105 | Not randomised | LAC 2 weeks | 71.6% (38/53) | 87.5% (35/40) | 23% (3/13) |
| Miki106 | Randomised | OAC, R AC 1 week | 87% (120/138) | 97.5% (119/122) | 6.3% (1/16) |
| Murakami107 | Randomised | RAC, LAC 1 week | 85.3% (227/266) | 94% (226/241) | 4% (1/25) |
| Peitz108* | Randomised | OAC 1 week | 48.5% (17/35) | 83% (10/12) | 30% (7/23) |
| Pilotto109 | Randomised | PAC 1 week | 85% (34/40) | 87% (33/38) | 50% (1/2) |
| Poon110 | Randomised | LAC 1 week | 84% (37/44) | 95% 37/39) | 0% (0/5) |
| Tankovic111 | Successive | OAC 1 week | 67.6% (69/102) | 79% (67/85) | 12% (2/17) |
| Total | 78.2% (1545/1975) | 87.8% (1495/1702) | 18.3% (50/273) | ||
*Second line treatment.
†Children.
O, omeprazole; L, lanzoprazole; P, pantoprazole; C, clarithromycin; M, metronidazole; R, ranitidine; A, amoxicillin; PPI, proton pump inhibitor.