Table 1.
Main characteristics in 11 consecutive patients with idiopathic pure hepatic sinusoidal dilatation
| Patient No(sex/age) | Specific features | Medications | ALT (×ULN) | GGT (×ULN) | AP (×ULN) | LA | Anticardiolipin antibodies* | ANA† (titre) | Sinusoidal dilatation | Activated perisinusoidal cells |
| 1 (F/31) | 2 previous early abortions. | None | 3 | 8 | 3.5 | + | IgG 52 and 45 GPL | 1/500 | Moderate | Absent |
| Thrombocytopenia. Familial thrombophilia | IgM <10 MPL | |||||||||
| 2 (F/29) | Unremarkable | None | 1.5 | 4 | 3.5 | + | IgG 40 and 45 GPL | 1/500 | Marked | Present |
| IgM <10 MPL | ||||||||||
| 3 (M/39) | Unremarkable | None | 3.2 | 2.5 | 4.1 | + | IgG 40 and 45 GPL | 1/250 | Moderate | Absent |
| IgM <10 MPL | ||||||||||
| 4 (F/52) | Unremarkable | None | 3.3 | 3.8 | 5 | + | IgG <10 GPL | Neg | Marked | Present |
| IgM 15 and 22 MPL | ||||||||||
| 5 (F/36) | Occult myeloproliferative disorder | Oestro-progestatives | 2 | 5 | 2.4 | Neg | Neg | Neg | Moderate | Absent |
| 6 (F/25) | Unremarkable | Oestro-progestatives | 2 | 6.3 | 3.3 | Neg | Neg | Neg | Marked | Present |
| 7 (M/60) | Unremarkable | None | 2.1 | 2 | 3 | Neg | Neg | Neg | Moderate | Absent |
| 8 (F/20) | Unremarkable | None | 3 | 7 | 3.1 | Neg | Neg | Neg | Marked | Present |
| 9 (F/47) | Unremarkable | None | 1 | 3 | 3 | Neg | Neg | Neg | Moderate | Absent |
| 10 (F/32) | Unremarkable | None | 3.1 | 7.3 | 2 | Neg | Neg | Neg | Marked | Present |
| 11 (F/31) | Unremarkable | Oestro-progestatives | 1 | 4 | 3 | Neg | Neg | Neg | Marked | Present |
F, female; M, male; ALT, serum alanine aminotransferase; GGT, serum gamma glutamyl transpeptidase; AP, serum alkaline phosphatase; ULN, times the upper limit of normal values; LA, lupus anticoagulant; ANA, antinuclear antibodies; Neg, not detectable.
*Positive when >10 GPL units for IgG and 10 MPL units for IgM in commercial ELISA (Cheshire Diagnostics, Chester, UK). Tested at least twice, six weeks apart.
†Immunofluorescence on Hep2 cells.