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Differences in rectal distension pain ratings (0 = no pain, 10 = unbearable pain) with and without painful heterotopic ice water immersion of the foot in 10 healthy subjects and five constipated (IBS-C) and five diarrhoeic (IBS-D) irritable bowel syndrome (IBS) patients. Negative values denote decreased rectal pain with heterotopic stimulation. Medians, interquartile ranges, and total ranges of repeated two distensions are shown. **p<0.01, healthy subjects versus IBS-C and IBS-D.
