Figure 3.

 Functional magnetic resonance imaging in a representative healthy control, and a constipated (IBS-C) and diarrhoeic (IBS-D) irritable bowel syndrome (IBS) patient during painful rectal distension without (top row) and with painful heterotopic stimulation (bottom row) at sections through the anterior cingulate (A) and insula (B). The anterior cingulate and insula cortices are encircled. Clusters with significant differences from baseline are depicted as colour coded values (see z scale bar).