Table 1.
Comparison of anamnestic, biochemical, and clinical data for 746 transferred patients, divided on the basis of age less than or greater than 40 years
| Age <40 years (n = 418) | Age ⩾40 years (n = 328) | |
| Sex (M/F) | 153 (37%)/265 (63%) | 121 (37%)/207 (63%) |
| Quantity of paracetamol (mg/kg) | 448 (329–694) | 500 (311–791) |
| Time to presentation at hospital (h) | 19 (12–36) | 24 (15–48)*** |
| Time to N-acetylcysteine (h) | 20 (12–38) | 30 (17–49)*** |
| Acute alcohol co-ingestion | 77 (18%) | 52 (16%) |
| Regular alcohol abuse | 57 (14%) | 161 (49%)*** |
| Acetylsalicylic acid co-overdose | 13 (3.1%) | 16 (4.9%) |
| Benzodiazepine co-overdose | 43 (10%) | 71 (22%)* |
| Opioid co-overdose | 18 (3.4%) | 23 (7.0%) |
| Accidental paracetamol overdose | 47 (11%) | 88 (27%)* |
| International normalised ratio | 2.9 (2.2–4.4) | 3.6 (2.6–5.5)*** |
| Alanine transaminase (U/l) | 8166 (2400–11340) | 6388 (3089–9560) |
| Creatinine (μmol/l) | 90 (76–150) | 160 (87–366)*** |
| Liver failure | 49 (12%) | 121 (37%)*** |
| Liver transplantation | 2 (0.5%) | 9 (2.7%)* |
| Death | 13 (3.1%) | 59 (18%)*** |
Values are given as median (1st quartile–3rd quartile).
*p<0.05, ***p<0.00001 (χ2 or Mann-Whitney’s test).