Rates of histological response in the three groups who received peginterferon alpha-2b plus ribavirin for 24, 36, or 48 weeks. Histological response was defined as ⩾2 point improvement in necroinflammatory score (grading). Histological response in shown for sustained virological responders (SVR), relapsers, non-responders (NR), and all patients. Bars represent change from baseline median total grading score.