Table 2.

 Adjusted relative risks (95% confidence interval) of symptomatic gall stone disease according to quintiles of energy adjusted intakes of glycaemic load among US men in the Health Professionals Follow up Study, 1986–1998

	Quintiles of glycaemic load
	1 (lowest)	2	3	4	5 (highest)	p for trend
Cases of GSD*	293	352	432	353	380	–
Person years	90 275	91 836	91 426	92 589	91 572	–
Model 1: age adjusted	1.00	1.09 (0.93, 1.28)	1.36 (1.17, 1.58)	1.24 (1.06, 1.44)	1.28 (1.10, 1.49)	0.02
Model 2: multivariate	1.00	1.09 (0.92, 1.29)	1.37 (1.16, 1.62)	1.25 (1.04, 1.50)	1.30 (1.07, 1.59)	0.03
Model 3: multivariate	1.00	1.13 (0.95, 1.33)	1.46 (1.23, 1.74)	1.38 (1.13, 1.67)	1.50 (1.20, 1.88)	0.0008
Model 4: multivariate	1.00	1.13 (0.95, 1.34)	1.46 (1.22, 1.75)	1.36 (1.10, 1.67)	1.46 (1.14, 1.87)	0.007

GSD, gall stone disease.

†Model 2, multivariate model included the following: age, body mass index, weight change during the past two years, physical activity, thiazide diuretics, non-steroid anti-inflammatory drugs, pack years of smoking, alcohol intake, caffeine intake, dietary fibre, protein intake, and total energy intake.

Model 3, model 2 with additional adjustment for saturated and trans fats.

Model 4, model 2 with additional adjustment for monounsaturated fat, polyunsaturated fat, saturated fat, and trans fat.