Table 5.
Putative UTR regulatory elements affected by cancer-associated UTR-SNPs.
| UTR-SNPs Ref (n = 20,304) | UTR-SNPs Var (n = 20,304) | CANCER Ref (n = 358) | CANCER Var (n = 358) | CANCER Ref (permutation pool, n = 92) | CANCER Var (permutation pool, n = 92) | |
| Total IRES | 5766 | 5802 | 92 | 94 | 20 | 20 |
| Gained | 625 | 11 | 3 | |||
| Lost | 589 | 9 | 3 | |||
| Total 15-LOX-DICE | 1788 | 1744 | 37 | 36 | 8 | 8 |
| Gained | 90 | 2 | ||||
| Lost | 134 | 3 | ||||
| Total TOP | 491 | 490 | 11 | 10 | 5 | 5 |
| Gained | 1 | |||||
| Lost | 2 | 1 | ||||
| Total K-Box | 287 | 287 | 3 | 3 | 0 | 0 |
| Gained | 16 | |||||
| Lost | 16 | |||||
| Total GY-Box | 174 | 168 | 5 | 5 | 0 | 0 |
| Gained | 9 | |||||
| Lost | 15 | |||||
| Total Brd-Box | 111 | 116 | 2 | 1 | 1 | 0 |
| Gained | 13 | |||||
| Lost | 8 | 1 | 1 | |||
| Total ADH-DRE | 44 | 50 | 1 | 1 | 1 | 1 |
| Gained | 6 | |||||
| Lost | 0 | |||||
| Total CPE | 26 | 30 | 1 | 1 | 0 | 0 |
| Gained | 12 | |||||
| Lost | 1 | |||||
| Total SECIS-2 | 12 | 10 | 1 | 0 | 1 | 0 |
| Gained | 1 | |||||
| Lost | 3 | 1 | 1 |
The results identify cis-regulatory elements located in the immediate vicinity of or at the UTR-SNP sites. UTR regulatory elements can be 'gained' or 'lost' when reference allele sequences are modified by cancer-associated SNPs.