Figure 4.

 In vivo fate of human hepatic progenitor cells. Human hepatic progenitor cells one month after transplantation in d-galactosamine treated mice contained (A) glucose-6-phosphatase (G-6-P, brown cytoplasmic staining), (B) glycogen (pink), (C) dipeptidyl peptidase IV (red-brown), and (D) gamma glutamyl transpeptidase (GGT, red/brown cytoplasmic staining). (E–H) Staining pattern for the same markers in sham transplanted (receiving only culture medium) control mice are shown. Note that G-6-P, glycogen, and GGT are non-human specific markers and are therefore also detected in sham transplanted mice. Tissue sections were counterstained with haematoxylin which stains mouse cells (blue). Magnification 60×.