Table 2.
Genotype 1 | Genotype 3 | p Value* | |||
Steatosis<10% (n = 80) | Steatosis⩾10% (n = 33) | Steatosis<10% (n = 13) | Steatosis⩾10% (n = 15) | ||
Age (y) | 41 | 49‡ | 44.5 | 43 | 0.0008 |
Sex ratio (M/F) | 1.22 | 1.54 | 1 | 2.75 | NS |
Disease duration (y)† | 18 | 18.5 | 16 | 17 | NS |
Alcohol (g/day) | 0 | 0 | 0 | 0 | NS |
BMI | 22.8 | 25.3‡ | 22.8 | 23 | 0.0003 |
ALT (IU/l) | 46 | 60 | 47 | 72 | NS |
Insulinaemia (µU/ml) | 4.8 | 9.4‡ | 5.4 | 5.2 | <0.0001 |
C peptide (nmol/l) | 0.6 | 0.9‡ | 0.5 | 0.6 | 0.01 |
HOMA IR | 1.1 | 2.1‡ | 1.1 | 1 | 0.001 |
Viral load (106Eq/ml) | 6.4 | 3.4 | 2.6 | 33.5‡ | 0.009 |
Activity score | 1 | 1 | 1 | 1 | NS |
Fibrosis score | 1 | 2‡ | 1 | 2‡ | 0.002 |
Percentage of steatosis | 0 | 20 | 1.5 | 40‡ | <0.0001 |
Hepatic iron (µmol/g) | 9.4 | 12.2 | 9.2 | 6.7 | NS |
Values are medians.
BMI, body mass index; ALT, alanine aminotransferase; HOMA IR, homeostasis model assessment for insulin resistance.
†In 80 patients with known risk factors.
*Fisher’s exact test or Kruskal-Wallis test; ‡Mann-Whitney test, p<0.05.