Skin conductance (SC) scores (with standard error bars) are shown at baseline, after balloon placement, and during sigmoid distension for control and irritable bowel syndrome (IBS) subjects, and for male and female IBS subjects. A significant condition × group interaction (p = 0.039) was seen, with higher SC in the IBS group versus the control group. A significant sex main effect (p = 0.010) was seen between male and female IBS patients, with higher SC in the male group.