Figure 6.
Effects of disrupting ASIC 1, 2, or 3 on markers of digestive function in conscious mice. (A) Left: increased time for half gastric emptying (t½), indicating a delay in ASIC1a -/- mice compared with wild-types (p<0.05, unpaired t test; (+/+) N = 8, (-/-) N = 14). These data are taken from Page et al.10 Right: unaltered faecal pellet output in ASIC1a -/- mice compared to wild-types (N = 3 each). (B) Left: unaltered gastric emptying (t½) in ASIC2 -/- mice compared with wild-types (NS; N = 10 each). Right: decreased faecal pellet output in ASIC2 -/- mice compared with wild-types (p<0.05, unpaired t test; N = 5 each). (C) Left: unaltered gastric emptying (t½) in ASIC3 -/- mice compared with wild-types (NS; (+/+) N = 11, (-/-) N = 10). Right: unaltered faecal pellet output in ASIC3 -/- mice compared with wild-types (N = 5 each).