Figure 4.

 Cotransfer of CD4⁺CD62L⁺ cells from cytosin-guanosin containing oligodeoxynucleotide (CpG-ODN) treated and untreated donor animals in SCID mice. Donor animals were treated with CpG-ODN (10 µg/day over five days) or left untreated and either CD4⁺CD62L⁺ cells from untreated or CpG-DNA treated donors or both were transferred to SCID recipients. As a negative control, SCID mice were injected with phosphate buffered saline (PBS). Histological score (A) and interferon γ (IFN-γ) secretion of isolated mesenteric lymph node cells (B) at the end of the experiment (eight weeks after transfer) are shown. *Significantly different from the group transferred with CD4⁺CD62L⁺ cells from untreated donor mice. Data presented were derived from three independent experiments, with 10–15 mice per group. ND, not detected.