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. 2005 Oct;54(10):1437–1444. doi: 10.1136/gut.2004.053587

Figure 4.

Figure 4

 REG Iα promoter activity in LoVo and SW403 cells in response to various cytokines. Cells were cotransfected with hREG Iα(−1195/+78)-Luc construct and Renilla luciferase plasmid pRL-TK (as a control for transfection efficiency). Forty eight hours later, cells were stimulated with interferon γ (IFN-γ), tumour necrosis factor α (TNF-α), interleukin (IL)-1β, IL-5, IL-6, IL-8, or IL-13. Luciferase activity was measured in extracts from transfected LoVo and SW403 cells and normalised to Renilla luciferase activity. All results are expressed as fold of the activity of the untreated cell group at the 0 hour time point. Vertical lines represent means (SEM) of four independent experiments. *p<0.05 versus control at the same time point.