(A) Frequency of flares according to hepatitis B virus (HBV) genotype. Among the most important genotypes in our study (HBV genotypes A, B, C and D (n = 255)), no significant difference in the frequency of flares was found. (B) Proportion of flares recorded during treatment among the flare population according to HBV genotype (n = 63). On-treatment flares predominantly occurred within genotype A. Genotype A versus genotype D, p = 0.029. (C) Flares leading to response according to genotype (n = 63). Genotype A versus genotype D, p = 0.050.