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Apple polyphenol extracts (APE) dose dependently prevented xanthine-xanthine oxidase (X-XO) induced damage to MKN 28 cells. MKN 28 cells were incubated with APE 10−7 to 10−4 M or with serum free medium (control) for three hours and then, after washing, with X (1 mM)-XO (50 mU/ml) or serum free medium for two hours. Mean (SD) from three separate experiments run in duplicate. *p<0.05 versus control; †p<0.05 versus X-XO.
