Figure 6.
Apple polyphenol extracts (APE) prevented indomethacin induced injury to the rat gastric mucosa. Rats were pretreated with APE 10−4 M in drinking water or vehicle (control) and then with indomethacin 35 mg/kg body weight subcutaneously and sacrificed three hours later. (A) Macroscopic appearance of gastric mucosa following indomethacin treatment in control vehicle treated rats. (B) Macroscopic appearance of the gastric mucosa following indomethacin treatment in APE treated rats. (C) Normal rat gastric mucosa. (D) Histological appearance of rat gastric mucosa following indomethacin treatment in control vehicle treated rats, showing extensive superficial epithelial damage and necrosis of gastric glands. (E) Histological appearance of rat gastric mucosa following indomethacin treatment in APE treated rats showing reduction in the extent of both superficial epithelial damage and necrotic lesions in the glandular area.