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. 2005 Aug;54(8):1098–1106. doi: 10.1136/gut.2004.062877

Figure 3.

Figure 3

 Role of tumour necrosis factor (TNF) in colonic interleukin 6 (IL-6) and norepinephrine (NE) secretion and influence of exogenous β-adrenoceptor (βAR) agonists. White (black) bars or symbols represent normal (colitic) animals. (A) Influence of NE on spontaneous IL-6 secretion (at least 12 colon strips were used per condition, n⩾18 mice). *p<0.05, **p<0.01 compared with controls (zero). (B) Influence of the βAR agonist isoproterenol on IL-6 secretion in the presence of 500 ng/ml of anti-TNF antibodies V1qH8. At least 24 colon strips were used (n⩾16 mice). ††p<0.005 compared with control without anti-TNF (zero). (C) Influence of anti-TNF on spontaneous NE release in normal and colitic mice. Two mice with 12 colon strips were used for each condition (n = 8 mice). *p<0.05 compared with controls. (D) Influence of electrical stimulation on NE release in normal and colitic animals. Two mice and eight colon strips were used for each condition (n = 8 mice).