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Concentration-response curves for the effects evoked by the protease activated receptor 4 (PAR4) activating peptide AYPGKF-NH2 on the longitudinal muscle of rat colon in the absence or presence of capsaicin. Capsaicin (10 μM) significantly antagonised the contractile response to the PAR4 agonist. The contractile effects are expressed as a percentage of the contraction to carbachol (CCh 10 μM). Each value is the mean (SEM) of five experiments. *p<0.05 compared with control values.
