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. 2003 Feb;52(2):275–282. doi: 10.1136/gut.52.2.275

Figure 8.

Figure 8

Effect of ethanol and its metabolite acetaldehyde on tissue inhibitor of metalloproteinase 2 (TIMP2) secretion by pancreatic stellate cells (PSCs). (A) Representative western blot for TIMP2 expression in cells incubated for 24 hours with either culture medium alone (Control), ethanol (50 mmol/l; E50), or acetaldehyde (200 μmol/l; A200). (B) Densitometry of all western blots (n=3 separate cell preparations) showed that both ethanol (E50) and acetaldehyde (A200) significantly increased TIMP2 secretion by PSCs compared with controls (E50, **p<0.01; A200 ***p<0.006).