Figure 6.

Effect of gliadin on tissue epithelial electrical resistance (Rt) in rabbit intestinal mucosa mounted in Ussing chambers. (A) Addition of the α-gliadin peptide led to a significant reduction in Rt which was detected after a few minutes of incubation. The same effect was observed with the gliadin toxic peptide 31–55 but not with the gliadin non-toxic peptide 22–39. No change in Rt was observed in the absence of gliadin (no gliadin). (B) Treatment with the zonulin inhibitor FZI/0 did not affect Rt. The effect of gliadin on Rt decrement was significantly inhibited when the tissue was pretreated with FZI/0.