TABLE 4.

Comparative analysis of the influences of transcriptional activity and variability on substitution rates between mammalian orthologs

Species pair	Ra	Rv	Ra|v	Rv|a	Ca	Cv	PCa	PCv
dN
Human	−0.186	0.201	−0.079	0.111	−6.341***	18.425***	41.52	58.48
Mouse	−0.222	0.252	−0.079	0.146	−7.389***	21.011***	44.01	55.99
Mouse	−0.210	0.251	−0.065	0.155	−6.380***	15.110***	45.21	54.79
Rat	−0.162	0.208	−0.042	0.139	−5.202**	12.695***	43.63	56.37
dS
Human	−0.093	0.165	0.012	0.137	1.034	16.001***	30.83	69.17
Mouse	−0.075	0.128	0.010	0.104	0.628	11.695***	36.30	63.70
Mouse	−0.075	0.133	0.014	0.111	0.028	8.676***	38.27	61.73
Rat	−0.093	0.132	−0.014	0.095	−2.492	8.157***	41.93	58.07
Jukes–Cantor distance
Human	−0.179	0.201	−0.070	0.116	−4.541*	19.266***	39.35	60.65
Mouse	−0.196	0.234	−0.059	0.143	−4.403*	20.752***	41.97	58.03
Mouse	−0.180	0.230	−0.043	0.152	−3.470*	14.960***	42.63	57.37
Rat	−0.148	0.188	−0.039	0.124	−3.738*	12.169***	42.10	57.90

Substitution rates such as d_N, d_S, and Jukes–Cantor distance were calculated as described in materials and methods. Transcriptional activity (a) and variability (v) are the predictor variables and the substitution rates are the response variables. See the Table 2 legend for details.