TABLE 5.

Comparative analysis of the influences of transcriptional-activity divergence and transcriptional-variability divergence on sequence divergence between paralogous genes

Species	Rad	Rvd	Rad|vd	Rvd|ad	Cad	Cvd	PCad	PCvd
dN
Human	0.126	0.258	−0.139	0.264	−2.443	3.322*	20.73	79.27
Mouse	0.140	0.230	−0.119	0.219	−4.489	7.131***	23.19	76.81
Rat	0.174	0.157	0.093	0.053	−1.466	19.670***	13.80	86.20
Fly	0.057	0.152	−0.358	0.382	−3.333	10.404***	4.14	95.86
Plant	0.348	0.351	0.017	0.048	1.338	3.939*	34.71	65.29
Yeast	0.132	0.051	0.124	−0.023	−0.037	0.907	44.21	55.79
dS
Human	0.176	0.298	−0.108	0.265	−0.749	3.140	1.55	98.45
Mouse	0.218	0.250	0.005	0.126	−1.721	3.274	29.65	70.35
Rat	0.164	0.179	0.059	0.093	0.764	18.286***	19.57	80.43
Fly	0.288	0.354	−0.228	0.310	0.812	6.031**	25.86	74.14
Plant	0.270	0.268	0.036	0.013	2.920	2.338	53.52	46.48
Yeast	0.141	0.097	0.105	0.026	0.721	0.968	49.22	50.78

Transcriptional-activity divergence (ad) and transcriptional-variability divergence (vd) are the predictor variables. Synonymous substitution rate (d_S) and nonsynonymous substitution rate (d_N) are the response variables. Transcriptional-activity divergence was measured as |z₁ − z₂|, where z₁ and z₂ mean the transcriptional activity of two paralogous genes. Transcriptional-variability divergence was measured as |CV₁ − CV₂|, where CV₁ and CV₂ mean the transcriptional variability of two paralogous genes. See the Table 2 legend for details.