Figure 6.
Kinetics of pro- and anti-inflammatory cytokines. Groups of mice were immunized subcutaneously with 0.5 LD50. Sera samples were collected on days 0, 7, 14, 21, and 28 days after immunization. The cytokines levels were determined as described in “Materials and Methods.” The experiment was repeated twice and each point represents the values of pooled sera from 5 animals ± SD. Statistical differences between the treatments were marked with asterisk (P < .001 for IL-6, IL-10, IFN-γ, and NO) and (P < .01 for TNF).