Figure 4.

Coordinated Endometrial Changes Associated with Endometriosis. Eutopic endometrial changes induced by the presence of ectopic endometriotic lesions can be classified as early responses, with increased levels of c-fos and CYR61, a transitional period, when the Pgr becomes decreased, and late responses when maintained down-regulation of Pgr may mediate down-regulation of the progesterone-regulated gene, HOXA10. (↑, represents up-regulation, ↓, represents down-regulation, and ↔, represents no change in gene expression.)