Skip to main content
PMC home page
British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1973 May;48(1):132–138. doi: 10.1111/j.1476-5381.1973.tb08230.x

Characterization of α-adrenoceptors in the myocardium

B G Benfey
PMCID: PMC1776086  PMID: 4146762

Abstract

1. In the driven rabbit left atrium α-adrenoceptors mediate the inotropic effect of phenylephrine and the prolongation of functional refractory period by sympathomimetic amines.

2. These receptors are highly sensitive to blockade by phentolamine and phenoxybenzamine.

3. Prolongation of functional refractory period is greater with the secondary amines, phenylephrine, adrenaline and epinine, than with the primary amines, norphenylephrine, noradrenaline and dopamine.

Full text

PDF
133

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BLINKS J. R. THE NATURE OF THE ANTAGONISM BY METHOXAMINE OF THE CHRONOTROPIC AND INOTROPIC EFFECTS OF CATECHOLAMINES. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1964 Apr 21;248:73–84. doi: 10.1007/BF00247060. [DOI] [PubMed] [Google Scholar]
  2. Benfey B. G., Carolin T. Effect of phenylephrine on cardiac contractility and adenyl cyclase activity. Can J Physiol Pharmacol. 1971 Jun;49(6):508–512. doi: 10.1139/y71-065. [DOI] [PubMed] [Google Scholar]
  3. Benfey B. G. Lack of relationship between myocardial cyclic AMP concentrations and inotropic effects of sympathomimetic amines. Br J Pharmacol. 1971 Dec;43(4):757–763. doi: 10.1111/j.1476-5381.1971.tb07211.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Benfey B. G., Varma D. R. Interactions of sympathomimetic drugs, propranolol and phentolamine, on atrial refractory period and contractility. Br J Pharmacol Chemother. 1967 Aug;30(3):603–611. doi: 10.1111/j.1476-5381.1967.tb02166.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Furchgott R. F. The pharmacological differentiation of adrenergic receptors. Ann N Y Acad Sci. 1967 Feb 10;139(3):553–570. doi: 10.1111/j.1749-6632.1967.tb41229.x. [DOI] [PubMed] [Google Scholar]
  6. Govier W. C. A positive inotropic effect of phenylephrine mediated through alpha adrenergic receptors. Life Sci. 1967 Jul 1;6(13):1361–1365. doi: 10.1016/0024-3205(67)90182-8. [DOI] [PubMed] [Google Scholar]
  7. Govier W. C., Mosal N. C., Whittington P., Broom A. H. Myocardial alpha and beta adrenergic receptors as demonstrated by atrial functional refractory-period changes. J Pharmacol Exp Ther. 1966 Nov;154(2):255–263. [PubMed] [Google Scholar]
  8. Govier W. C. Myocardial alpha adrenergic receptors and their role in the production of a positive inotropic effect by sympathomimetic agents. J Pharmacol Exp Ther. 1968 Jan;159(1):82–90. [PubMed] [Google Scholar]
  9. Govier W. C. Prolongation of the myocardial functional refractory period by phenylephrine. Life Sci. 1967 Jul 1;6(13):1367–1371. doi: 10.1016/0024-3205(67)90183-x. [DOI] [PubMed] [Google Scholar]
  10. KOCH-WESER J., BLINKS J. R. THE INFLUENCE OF THE INTERVAL BETWEEN BEATS ON MYOCARDIAL CONTRACTILITY. Pharmacol Rev. 1963 Sep;15:601–652. [PubMed] [Google Scholar]
  11. Kabela E., Jalife J., Peon C., Cros L., Mendez R. The adrenergic receptors of the coronary circulation in the isolated dog heart. Arch Int Pharmacodyn Ther. 1969 Oct;181(2):328–342. [PubMed] [Google Scholar]
  12. Krell R. D., Patil P. N. Combinations of alpha and beta adrenergic blockers in isolated guinea-pig atria. J Pharmacol Exp Ther. 1969 Dec;170(2):262–271. [PubMed] [Google Scholar]
  13. LEE W. C., YOO C. S. MECHANISM OF CARDIAC ACTIVITIES SYMPATHOMIMETIC AMINES ON ISOLATED AURICLES OF RABBITS. Arch Int Pharmacodyn Ther. 1964 Sep 1;151:93–110. [PubMed] [Google Scholar]
  14. McNeill J. H., Davis R. S., Muschek L. D. Phenylephrine effects on cardiac contractility adenyl cyclase, and phosphorylase. Arch Int Pharmacodyn Ther. 1972 Jun;197(2):317–327. [PubMed] [Google Scholar]
  15. TRENDELENBURG U., DELASIERRA B. G., MUSKUS A. MODIFICATION BY RESERPINE OF THE RESPONSE OF THE ATRIAL PACEMAKER TO SYMPATHOMIMETIC AMINES. J Pharmacol Exp Ther. 1963 Sep;141:301–309. [PubMed] [Google Scholar]
  16. Wenzel D. G., Su J. L. Interactions between sympathomimetic amines and blocking agents on the rat ventricle strip. Arch Int Pharmacodyn Ther. 1966 Apr;160(2):379–389. [PubMed] [Google Scholar]
  17. Yoo C. S., Lee W. C. Blockade of the cardiac action of phenylephrine by bretylium or cocaine. J Pharmacol Exp Ther. 1970 Apr;172(2):274–281. [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES