Fig. 2.
Increased sensitivity to thermal and mechanical stimuli after L5 SNL. Graphs illustrate mean (±SEM) of difference in withdrawal latency (A) or pressure threshold (B) between ipsilateral–contralateral hindpaw of SNL and sham surgery rats or left–right in naïve control rats. Day “pre” and “0” represent the baseline measurements before SNL surgery. There is no significant difference in the baseline value for both thermal (A) and mechanical (B) testings among three groups of rats. All of the post L5 SNL data points for both thermal and mechanical sensitivity are significantly different (P < 0.05, two-way ANOVA with Tukey post hoc comparison) from baseline at time “pre”, and from sham and naïve controls within each post-operative day.