Abstract
1. The β-adrenoceptor blocking properties of 1-(p-allylphenoxy)-3-isopropylamino-2-propanol hydrochloride (H 64/52) on the cardiovascular and bronchomotor responses to isoprenaline have been determined in the anaesthetized dog.
2. H 64/52 selectively blocked the isoprenaline-induced increase in heart rate, contractile force and reduction in airway pressure in the same dose range.
3. H 64/52 produced a minimal blockade of vascular β-adrenoceptors which was apparent only when the isoprenaline-induced fall in diastolic pressure was considered. No significant vascular β-adrenoceptor blockade with H 64/52 could be shown with the femoral arterial flow or hind-limb perfusion studies.
4. These results further support the hypothesis that several different β-adrenoceptor subtypes exist in the dog. The β-adrenoceptors subserving cardiac stimulation and bronchodilation appear to be similar and both differ from the β-adrenoceptor subserving vasodilatation.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Ablad B., Brogård M., Carlsson E., Ek L. Beta-adrenergic receptor blocking properties of three allyl-substituted phenoxypropanolamines. Eur J Pharmacol. 1970;13(1):59–64. doi: 10.1016/0014-2999(70)90183-4. [DOI] [PubMed] [Google Scholar]
- Boissier J. R., Advenier C., Giudicelli J. F., Viars P. Studies on the nature of the bronchial -adrenoreceptors. Eur J Pharmacol. 1971 Jun;15(1):101–109. doi: 10.1016/0014-2999(71)90084-7. [DOI] [PubMed] [Google Scholar]
- Bonn J. A., Turner P., Hicks D. C. Beta-adrenergic-receptor blockade with practolol in treatment of anxiety. Lancet. 1972 Apr 15;1(7755):814–815. doi: 10.1016/s0140-6736(72)90799-4. [DOI] [PubMed] [Google Scholar]
- Dungan K. W., Cho Y. W., Gomoll A. W., Aviado D. M., Lish P. M. Pharmacologic potency and selectivity of a new bronchodilator agent: soterenol (MJ 1992). J Pharmacol Exp Ther. 1968 Dec;164(2):290–301. [PubMed] [Google Scholar]
- Dunlop D., Shanks R. G. Selective blockade of adrenoceptive beta receptors in the heart. Br J Pharmacol Chemother. 1968 Jan;32(1):201–218. doi: 10.1111/j.1476-5381.1968.tb00444.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Farmer J. B., Levy G. P. Differentiation of beta-adrenoreceptors by the use of blocking agents. J Pharm Pharmacol. 1970 Feb;22(2):145–146. doi: 10.1111/j.2042-7158.1970.tb08414.x. [DOI] [PubMed] [Google Scholar]
- Hinds L., Katz R. L. Dissociation of tracheobronchial and cardiac effects of some beta-adrenergic stimulants. Anesthesiology. 1971 May;34(5):445–449. doi: 10.1097/00000542-197105000-00019. [DOI] [PubMed] [Google Scholar]
- Lands A. M., Luduena F. P., Buzzo H. J. Differentiation of receptors responsive to isoproterenol. Life Sci. 1967 Nov 1;6(21):2241–2249. doi: 10.1016/0024-3205(67)90031-8. [DOI] [PubMed] [Google Scholar]
- Levy B. The adrenergic blocking activity of N-tert.-butylmethoxamine (butoxamine). J Pharmacol Exp Ther. 1966 Mar;151(3):413–422. [PubMed] [Google Scholar]
- Levy B., Wilkenfeld B. E. An analysis of selective beta receptor blockade. Eur J Pharmacol. 1969 Feb;5(3):227–234. doi: 10.1016/0014-2999(69)90142-3. [DOI] [PubMed] [Google Scholar]
- Levy B., Wilkenfeld B. E. The actions of selective beta-receptor antagonists on the guinea pig trachea. Eur J Pharmacol. 1970 Jul 1;11(1):67–74. doi: 10.1016/0014-2999(70)90255-4. [DOI] [PubMed] [Google Scholar]
- Nakano J., McCloy R. B., Jr Effect of quinidine on cardiovascular dynamics. Arch Int Pharmacodyn Ther. 1967 Aug;168(2):400–416. [PubMed] [Google Scholar]
- Wasserman M. A., Levy B. Selective beta adrenergic receptor blockade in the rat. J Pharmacol Exp Ther. 1972 Aug;182(2):256–263. [PubMed] [Google Scholar]