Abstract
1 Chronic administration of ethanol to mice by inhalation induced tolerance to ethanol and produced an increase in the concentration of brain monoamines.
2 Withdrawal of ethanol from dependent mice caused behavioural changes associated with a further transient rise in brain monoamine concentrations which then declined to control levels.
3 Inhibition of the withdrawal syndrome by the administration of ethanol postponed the changes in monoamines associated with withdrawal.
4 Administration of inhibitors of catecholamine synthesis before withdrawal of ethanol modified the withdrawal syndrome.
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Selected References
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