Figure 6.

Consequences for B cell activation and the development of the IM-like disease. The proportion of CD19⁺ B cells expressing the early activation marker CD69 was determined for the MLN and spleen (A), whereas the frequency of Vβ4⁺CD8⁺ T cells was measured for the spleen and PBL compartments (B). Total CD8⁺ T cell numbers in the PBL is shown in C. The mice had been doubly primed with vacc-p56 and WSN-p56 before the γHV-68 challenge (see Fig. 3 legend). Earlier studies have established that these Vβ4⁺CD8⁺ T cells are not specific for the known peptide epitopes of γHV-68 (19, 20).